Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

1,4-benzothiazepine Analogues: Synthesis, Characterisation and Antimicrobial Evaluation

Author(s): Basavaraju, Dileep Kumar A, Renuka N, Vagish CB, Ajay Kumar K

An efficient and accessible procedure for the synthesis of 1,4-benzothiazepines was developed. An acid catalyzed reaction of chalcones and 2-aminothiophenol produced 1,4-benzothiazepines in good yields. The synthesized new compounds were characterized by spectral studies and elemental analysis; and were screened in vitro for their antimicrobial potencies against different bacteria and fungi species.


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