Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

2,2-Dichloro Carboxymethyl Chitosan with Crosslinker Urea-Terephthalic acid as Wound Healing on Mice

Author(s): Suyanto, Khusnul Ain, Syaikhu Akhmad Husen, Zakki Fahmi M

A syntactical research into 2.2-dichloro carboxyl methyl chitosan-urea-phthalic acid (DCMChi-UTER) was conducted. This chitosan derivate compound was a graft-crosslink polymer. Then pasta/cream was extracted from this compound by adding Vaseline and inserting it into a homogenizer, the process whose result is Vaseline-DCMChi-UTER paste. The paste concentration is 10% and 20%. From the wound healing test on mice given a 1 cm-long incision on the right back which was later treated with the paste once a day, a good condition results macroscopically and the histology shows that recovery takes place on the fourth day of the application, the wound nearly recovers (the wound nearly closes) totally on the seventh day, and the wound recovers (the wound totally closes) on the fourteenth day after the application. The histology analysis shows that when viewed from inflammatory cells, reepithelization, torn epidermal cells, keratin migration, scar tissue, fibro proliferative tissue, broken collagen tissue, hair follicle growth and the number of fibroblast cells, it turns out that this medicine is better than the positive control.


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