Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

2,9,16,23-tetra-N-(4-bromo-2-methoxyphenyl)benzamide substituted metallophthalocyanines: Synthesis, characterization, antimicrobial and antioxidant activity

Author(s): B. Chidananda, K. R. Venugopala Reddy, K. M. Pradeep, M. N. K. Harish, C. D. Mruthyunjayachari, S. D. Ganesh, N. S. Vijaykumar and P. Malthesh

The scheming and structural adornment of soluble metallophthalocyanines peripherally substituted with 4-bromo-2- methoxyaniline via amide bridged molecule is described. These molecules display admirable solubility in organic solvents such as methanol, ethanol, tetrahydrofuran, dimethylformamide and dimethyl sulfoxide and compound was characterized by a wide range of spectroscopic methods in addition to elemental analysis. Synthesized all of the new phthalocyanine compounds have been set to antimicrobial activity and antioxidant. The antioxidant activities of designed metallophthalocyanines were investigated by in vitro antioxidant assays such as free radical scavenging ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH). The title metallophthalocyanines (5-7) were screened against Gram-positive bacteria with comparing standard Streptomycin as reference. Antifungal activities against two different fungi have been evaluated and compared with Flucanazole as reference.


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