Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


3d transition metal complexes of 3-hydrazino-benzoxazine-2-one: Synthesis, characterization and antifungal activity

Author(s): V.Haribabu, P.V. Anantha Lakshmia, and V. Jayatyaga Raju

A new series of Cr(III), Mn(II), Fe(II), Co(II) and Ni(II) complexes of the 3-hydrazino benzoxazine-2-one (HBO) were prepared and characterized. The ligand behaves as a bis bidentate ONNN donor. The nature of bonding and the stereochemistry of the complexes have been deduced from elemental analyses, thermal, infrared, electronic spectra, magnetic susceptibility and conductivity measurements. An octahedral geometry was suggested for all the complexes. All the complexes show subnormal magnetic moments. The ligand, HBO, and its complexes were tested against Neurospora crassa, a non-pathogenic fungus. The Mn(II) and Co(II) complexes exhibited higher antifungal activities than the parent ligand.

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