Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

6-(4-(4-Substituted phenylpiperazin-1-yl)butoxy)benzo[d][1,3]oxathiol-2-one Synthesis and biological evaluation as potential antipsychotic agents

Author(s): Radha Charan Dash, Sharad H. Bhosale and Kakasaheb R. Mahadik

A series of 6-(4-(4-substituted phenylpiperazin-1-yl)butoxy)benzo[d][1,3]oxathiol-2-one was synthesized. The anti-dopaminergic and anti-serotonergic activities of the synthesized compounds were evaluated as an approach to identify novel antipsychotic agent. 6-(4-(4- Substituted phenylpiperazin-1-yl)butoxy)benzo[d][1,3]oxathiol-2-ones were synthesized by reacting 6-(4-chlorobutoxy)benzo[d][1,3]oxathiol-2-one with substituted phenyl piperazines and were characterized by IR, 1H-NMR, C13-NMR, MS and elemental analysis. The antidopaminergic activity was evaluated by their ability to inhibit apomorphine induced climbing behavior and the anti-serotonergic activity of synthesized compounds was assessed by studying inhibition of 5-HTP induced head twitches in mice. The intensity of catalepsy induced by synthesised compounds was evaluated against haloperidol induced catalepsy. The pharmacological testing revealed that the compound 4l, 6-(4-(4-(2,3-dichlorophenyl)piperazin- 1-yl)butoxy)benzo[d][1,3]oxathiol-2-one and 4n 6-(4-(4-(2,3-dimethylphenyl)piperazin-1- yl)butoxy)benzo[d][1,3]oxathiol-2-one showed better antipsychotic profile with lower incidence of catalepsy induction.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş