Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


A CaO catalyzed facile one pot synthesis of 2-aminothiophenes using Gewald reaction

Author(s): G. A. N. K. Durgareddy, R. Ravikumar*, S. Ravi and Srinivas R. Adapa

A simple and efficient protocol for the synthesis of 2-aminothiophenes via Gewald reaction from ketones with an active nitrile or ethyl ester and elemental sulphur using CaO, a cheapest catalyst ever reported in moderate to good yield in ethanol under reflux in 1 to 1.5 h.

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