Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

A conventional synthesis and characterization of so me novel substituted N - {(2-methyl/mercapto--1 H -benzo[ d ]imidazol-1-yl)methyl}substituted benzenamine, N -{(2-methyl/mercapto--1 H -benzo[ d ]imidazol-1-yl)(substituted phenyl)methyl}substituted benzenamine as potential cytotoxic agents

Author(s): *Vikash Kumar Chaudhari and Devender Pathak

Benzimidazoles are an important group of heterocycl ic compounds which are biologically active. The mai n objective to synthesized a new series of N-{(2-Meth yl/Mercapto-1H-benzo[d]imidazol-1-yl)methyl}substit uted benzenamine (1a-1c) & (3a-3c), N-{(2-Methyl/Mercapto-1H-benzo[d]imidazol-1-yl)(su bstituted phenyl)methyl} substituted benzenamine (2a-2d) & (4a-4d) were synthesized. All the newly synthesized compou nds were characterized by FTIR, 1 H NMR, mass spectral analysis and elemental analysi s. All the compounds were screened for anticancer activity against A549 cell line by S RB assay of which compounds 1a, 1b, 2a, 2b, 2c, 2d, 3a, 3b, 4a, 4b, 4c and 4d showed promising cytotoxic potential.


ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?