Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


A green alternative approach for synthesis of 2-substituted-5,6- dihydro-4H-1, 3-oxazines catalyzed by NBS: Ultra Sonication

Author(s): Kuruva Chandra Sekhar, Syed Rasheed, Lacchireddy Venkata Ramana, Chamarthi Naga Raju

Commercially available N-Bromosuccenamide (NBS)is reported as an extremely efficient catalyst for the synthesis of 2-aryl/hetero aryl-5, 6-dihydro-4H-1,3-oxazines by ultrasound irradiation of 3-aminopropanol with different aryl/ heteroaryl aldehydes took place in one pot under aqueous medium at 70 oC, gives high yields in shorter reaction times. The reactions proceeded with extremely high efficiency under mild conditions and gave good yields. The proposed methods were found to be suitable and accurate for rapid synthesis of substituted 5, 6- dihydro-4H-1,3-oxazines derivatives available. All the newly synthesized compounds were characterized by IR, 1H and 13C NMR.

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