Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

A new validated simultaneous RP- HPLC method for estimation of escitalopram oxalate and etizolam in bulk and table dosage form

Author(s): Prasenjit Mondal, Santhosh. B, Sobha Rani Satla and Ramakrishna Raparla

A reversed phase HPLC method has been developed for the simultaneous determination of Escitalopram oxalate and Etizolam by using C18 (250 x 4.6 mm) column and mobile phase of 0.02M Potassium dihydrogen orthophosphate: Acetonitrile (40:60) at 254 nm. Retention times of Escitalopram oxalate and Etizolam were 2.8 min and 4.1 min respectively with resolution of 6.52. This method shows to be linear (r2>0.99), precise (RSD<2%), accurate (recovery of 99.8% of Escitalopram oxalate and 99.46% of Etizolam), specific and robust. The Escitalopram oxalate contains in tablets was 99.8 % where Etizolam contains was 99.33 %


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