Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


A simple and efficient method for the a-sulfenylation of acyl arenes

Author(s): Umanadh Yapuri, Sreelatha Vanjivakaa, Sadanandam Palle, Ramana Kumar K and Omprakash Gudaparthia

A highly efficient one-pot procedure for a-Sulfenylation of acyl arenes is described. a-Sulfenylation of ketones was proceed via a- bromination of ketones followed by water promoted SN2 displacement of a-halogenated carbonyl compounds with thiols. This method serves as convenient new method a-Sulfenylation of ketones and is compatible with a wide range of thiol and acyl arene functionality.

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