Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

A simple visible spectrophotometric determination of Sumatriptan Succinate from pharmaceutical formulations

Author(s): B. Kalyanaramu and K. Raghubabu

A simple, sensitive and cost effective visible spectrophotometric method was developed for the estimation of sumatriptan succinate in bulk and dosage forms. The method is based on the formation of purple red colored species with sodium nitroprusside –acetaldehyde reagent exhibiting maximum absorption at 552 nm. Beer’s law obeyed in the concentration range of 4 - 20 μg/ml. commercially available tablets were analysed, the results obtained by the proposed method were in good agreement with the labeled amounts. These methods are reproducible with an accuracy of ±1 %.


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