Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Amberlyst ® 15 DRY Resin: A green and recyclable catalyst for facile and efficient one-pot synthesis of 3, 4-dihydropyrimidin-2(1H)-ones

Author(s): Srinivasa Rao Jetti, Neelaiah Babu G., Pradeep Paliwal, Anjna Bhatewra, Tanuja Kadre, Shubha Jain

Ion exchange resin catalyzed multicomponent Biginelli reaction is studied for the synthesis of 3, 4-dihydropyrimidin-2-ones. Among the various solid acid catalysts Amberlyst® 15 DRY was found to be most efficient, recyclable and environmentally benign heterogeneous catalyst regarding reaction time, yield and ease of work up procedure.


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