Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

An ecofriendly estimation of valsartan and hydrochlorothiazide in pharmaceutical dosage form by absorption ratio method

Author(s): Tanushree Banerjee, Bhaskar Banerjee, Angshu Banerjee

A new, simple, ecofriendly, economical and accurate absorption ratio method was developed and validated by using hydrotropic solubilizing agent (8M ammonium acetate solution) for the determination of valsartan and hydrochlorothiazide in tablets. Hydrotropy is one of the solubility enhancement techniques, which enhance solubility of poorly water-soluble drugs to many folds with use of hydrotropes. In the present investigation, hydrotropic solution of ammonium acetate (8M) was employed as solubilizing agent to solubilize valsartan and hydrochlorothiazide (poorly water-soluble drugs) fine poder and tablet dosage form. Calibration curves for valsartan and hydrochlorothiazide over concentration range of 2-20 μg/ml were plotted and molar absorptivity for both the drugs were calculated at both the wavelengths of 270.5 nm (l-max of hydrochlorothiazide) and 231.5 nm (iso- absorptive point). The results of analysis have been validated statistically and by recovery studies. The value of standard deviation was satisfactory and recovery studies ranging from 99.05-102.23% for valsartan and 97.42- 100.22% for hydrochlorothiazide were indicative of the accuracy and precision of the proposed method. The results of the assay are in good agreement with the label amount. The method was found to be simple, rapid, and accurate and can be adopted in routine analysis of these drugs in formulations. Due to these attributes, the proposed method could be used for routine analysis of these drugs in combined dosage forms.


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