Hydrotropy is one of the solubility enhancement techniques, which enhance solubility of poorly water-soluble drugs to many folds with use of hydrotropes. Three simple, accurate and economic methods; simultaneous equation, Q absorbance and first order derivative method have been described for the simultaneous spectrophotometric estimation of poorly water soluble drugs Olmesartan medoxomil and Hydrochlorothiazide in tablet dosage form. A mixed hydrotropic blend of 25% w/v urea and 25% w/v sodium acetate was used for the quantitative determination. Method A involved simultaneous equation method, the two wavelengths 256.8 nm (λmax of Olmesartan medoxomil) and 271.6 nm (λmax of Hydrochlorothiazide) were selected for the formation of Simultaneous equations. Whereas method B involved formation of Q absorbance equation at isobestic point (263.9 nm). Method C is First order Derivative Spectrophotometric method in which derivative amplitudes were measured at selected wavelengths (257.2 nm for Hydrochlorothiazide and 271.6 nm for Olmesartan medoxomil). Linearity was observed in the concentration range of 3-21, 3-21, 4-28 μg/ml for Olmesartan medoxomil and 2-14, 3-21, 5-35 μg/ml for Hydrochlorothiazide by method A, B and C respectively. The proposed methods have been applied successfully to the analysis of cited drugs in pharmaceutical formulations. Recovery study was performed to confirm the accuracy of the methods. The methods were validated as per ICH guidelines.