Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


An efficient and clean synthesis of N'-arylidene-6-hydroxy-2- methylpyrimidine-4-carbohydrazides

Author(s): E. Laxminarayana1, T.Kranthi Kumar1, S. Shivashankar2 and M.Thirumala Chary2*

6-Chloro-2-methylpyrimidin-4-ol (1) reacts with carbon monoxide to give Ethyl-6-hydroxy-2- methylpyrimidine-4-carboxylate (2). This ester is converted into hydrazide 6-Hydroxy-2- methylpyrimidine-4-carbohydrazide (3) and coupled with different aldehyde to obtain N'- Arylidene-6-hydroxy-2-methylpyrimidine-4-carbohydrazides (4

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