Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


An efficient one-pot synthesis of 2, 4, 6-triaryl pyridines and their in vitro antimicrobial activity

Author(s): Bhaskar S. Dawane, Shankaraiah G. Konda and Raghunath B. Bhosale

A simple and efficient synthesis of 2,4,6-triaryl pyridines is described by the one-pot condensation of substituted acetophenones, 1-phenyl-3-(4’-hydroxy/chloro phenyl) pyrazol-4- carboxaldehyde, ammonium acetate and solid sodium hydroxide in polyethylene glycol (PEG- 400) as green reaction solvent. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

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