Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


An efficient one-pot synthesis of 2,4,5-trisubstituted imidazole catalysed by citric acid

Author(s): Nora CHOUHA, Taoues BOUMOUD, Imane TEBABEL, Boudjemaa BOUMOUD and Abdelmadjid DEBACHE

From synthesis view-point, multicomponent reactions catalysed by metal-free catalysts have proven themselves better alternatives because of better economical, ecological and toxicological profiles. In this context, herein, we report a facile and efficient synthesis of 2,4,5-triarylsubstituted imidazole derivatives via three-component condensation reaction in the presence of a catalytic amount of citric acid.

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