Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

An Efficient Synthesis of β-Enaminoketone/Ester Under Grinding Condition Using Calcium Bromide as Solid Support Catalyst

Author(s): Pramod Kulkarni, Ajay Jadhav

Calcium bromide was used as a catalyst in the synthesis of β-enaminoketone/ester from 1,3-dicarbonyl compound and amines. The reaction was carried out in mortar and pestle at room temperature. The process is mild, efficient, eco-friendly and cost-effective with the use of very small amount of catalyst; avoiding use solvent, simple product separation, and high yield. We compare this grinding reaction condition with reaction in solvent and we got better results with the grinding reaction condition


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