Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


An efficient synthesis of formyl coumarins by microwave irradiation methodduff formylation

Author(s): Omprakash S. Chavan, S. B. Chavan and M. A. Baseer

A series of formyl derivatives of Coumarins have been synthesized by Duff formylation method, in this method hydroxyl Coumarins was reacted with hexamethylene tetramine (HMTA) in presence of tri-fluoroacetic acid (TFAA) under microwave irradiation techniques. The structures of all synthesized compounds were confirmed by IR, NMR, Mass and CHN analysis. This is a newly developed efficient synthesis of formyl Coumarins under microwave irradiation technique by Duff formylation method.

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