Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


An expeditious synthesis of riociguat, A pulmonary hypertension drug

Author(s): Veerareddy Arava and Surendrareddy Gogireddy

Riociguat: A potent, Oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension, is prepared from commercially available 2-Chloronicotinic acid via (E)-2-(2-chloropyridin-3-yl)-2-(2-(2-fluorobenzyl) hydrazono) acetamide

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