Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

An Improved Process for Preparation of Key Intermediates in the Synthesis of Praziquantel

Author(s): Venkatareddy Gayam, Subban Ravi

An improved greener method using toluene as the solvent for the bulk preparation of intermediates 2 and 3 for the synthesis of praziquantel (PZQ), the only drug used for schistosomiasis has been reported. The method will be of significant importance in the manufacture of PZQ by lowering manufacturing costs and reducing environmental problems.


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