Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Annonaceous Acetogenins as a new anticancer agent

Author(s): Wesam S. Qayed, Ahmed S. Aboraia, Hamdy M. Abdel-Rahman and Adel F. Youssef

In spite of the many advances in modern scientific medicine, plant-based traditional medicine still plays an important role in the health care. The acetogenins of Annonaceae are known by their potent cytotoxic activity. In fact, they are promising candidates as a new future generation of antitumoral drugs to fight against the current chemiotherapic resistant tumors. The present review will describe the source and chemistry of Annonaceousacetogenins, their diverse biological activities and their anticancer mechanism of action with highlighting on their toxicity and previously reported total synthesis


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