Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Anthelmintic activity of transition metal complexes of some benzamides

Author(s): E. Khatiwora, K. Mundhe, N. R. Deshpande, R. V. Kashalkar

Copper and cobalt complexes of four benzamides, [N-(3’-nitrophenyl) (piperidin-1"-yl) methyl] benzamide, [N (piperidin1"-yl) (p-tolyl ) methyl] benzamide, [N-(4’ – chloro - phenyl) (piperidin-1"-yl) methyl] benzamide and [N- (4’-methoxy- phenyl) (piperidin-1"-yl] benzamide have been synthesized. Anthelmintic activity of benzamides and their complexes have been evaluated against Indian Earth worm species Eicinia foetida. The results reveal a dose dependent increase in activity of the compounds at 5, 10 and 20 mg/ml concentration. All the metal complexes exhibit significant activity in dose dependant manner. Both cobalt and copper complexes are found to be more active as compared to ligand and standard drug albendazole.

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