Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Anti microbial study of newly formed complexes of transition and inner transition metals with antiulcer drug and RNA bases

Author(s): Sarika Verma, Sarita shrivastva and Poonam Rani

Binary and Ternary complexes of Transition metals (Co, Cu, Cr, Cd, Mn) and Inner transition metals (Th, Ce, Gd) have been synthesized by reacting their metal salts with antiulcer drug, namely Omeparazole (OME) and RNA bases namely Uracil(URA)/Adenine(ADE). The complexes are colored solids which are insoluble in cold water and freely soluble in DMF, DMSO and Ethanol. In this study, these metal complexes have been screened for their antibacterial activity towards Pseudomonas aeruginosa, Pseudomonas diminuta, Escherichia Coli , Streptococus Faecali Bacterias and antifungal activity towards Aspergillus Nidulans Fungi respectively .The results obtained were compared with that of the parent drug .The study reveals that the metal chelates (complexes) shows a remarkable resistance as compared with the parent drug.


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