Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Anti oxidant activity of [6-chloro-2-(methylsulfanyl) pyrimidine-4-amine]cobalt(II)] complex

Author(s): Suzan K. Oudah, Hassan T. Mohamed and Wasfi A. Al-Masoudi

Sodium nitrite is widely used as color fixative and preservative in meat and fish.Impairment of hepatic function and disturbances in lipid metabolism are well recognized advers effecte of sodium nitrite. The aim of this study is to investigate the role of [6 –chloro-2 (methylsulfanyl) pyrimidine -4-amine]cobalt(II)] complex, in preventing the oxidation of hemoglobline to methomoglobline in vitro, and preventing the disturbances in lipid metabolism induce by sodium nitrite toxicity in mice. The cobalt(II)complex of pyrimidine derivative causes inhibit sodium nitriteinduce methemoglobine formation, Moreover the complex cuases significant increase of total cholesterol, TG and LDL, while HDL significantly reduced.


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