Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Anticarcinogenic Effects and Design of Dinuclear Chelates of New Guanidine Derivatives

Author(s): Sabreen Mohamed El-Gamasy, Samar Ebrahim Abd-El Razek

New series of dinuclear transion metal chelates of guanidine ligand have been synthesized and characterized by spectroscopic measurements such as: 1H-NMR, mass spectra, IR, UV-Visible, ESR, magnetic moments and conductance measurements, as well as elemental and thermal curves (DTA and TGA). The IR data clarify that, the Schiff base is a neutral bidentate or monobasic bidentate ligand attached to the ions of metal through the (N) atom of azomethine and (O) atom of hydroxyl in deprotonated or protonated form adopting tetragonal distorted octahedral geometries. Solutions of molar conductances in DMF clarified that, the chelates are not electrolytes. The ESR spectra of solid Cu(II) chelates (2) and (4) show an axial type. However, Mn(II) complex (8) show isotropic type indicating distorted octahedral geometry. Anticarcinogenic effects of the ligand chelates have been carried out. Chelates show enhanced activity in comparison to the ligand of guanidine and standard drug.


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