Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Antifungal Activity of Condensed Benzothiazole and Its Derivatives

Author(s): Anil B Chidrawar

A simple and efficient method have been used for the synthesis of 2-substituted derivatives of 3-cyano-4,14-diimino-2-methylthio-10-nitropyrimido [2,3-b] pyrazolo [3,4-e] pyrimido [2,3-b] [1,3] benzothiazole have been prepared through one Step Multicomponent reaction by heating a mixture of 3-amino-4-imino-8-nitro-2H-pyrazolo[3,4-e]pyrimido[2,3-b][1,3]benzothiazole and bis (methylthio) methylene malononitrile independently with aromatic amines/phenols/heterylamines/compounds containing active methylene group respectively in the presence of dimethyl formamide and catalytic amount of anhydrous potassium carbonate. All these newly synthesized compounds were screened for anticancer activity.


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