Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Antimicrobial Activity of Some Diaminobenzoic Acid Derivatives

Author(s): Shefali Arora, Pramod Chand Pant, Shailey Singhal, Mamta Latwal, Shilpi Agarwal, Deepak Kumar

Heterocyclic compounds constitute the largest family of organic compounds, regardless of structure and functionality. Heterocyclic compound are of particular interest in medicinal chemistry and this has catalyzed the discovery and development of many new heterocyclic compounds. The compound bearing thiazole and oxazole moiety have been found to possess antimicrobial, antitubercular and anti-inflammatory activity. Benzimidazole derivatives of 3,4-diaminobenzoic acid derivative (IV a, b), have been synthesized which are tautomer of each other, after the synthesis of 4-isothiocyanato-3-methylbutanal (CIT), a reagent. All the synthesized derivatives have been screened with various bacterial and fungal strains viz. Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Bacillus typhi, Candida albicans, Penicillium chrysogenum, Saccharomyces cerevisiae, Penicillium chrysogenum, Aspergillus niger. After the antimicrobial studies, it were found that compound (IV)a can be act as a standard drug against fungal strain Candida albicans, Sacharomyces cerevisiae, as it showed more inhibition zone than the standard drug Ketoconazole respectively. Compound (IV ) a showed very good activity against fungal strains Aspergillus niger and Penicillium chrysogenum as these derivatives showed comparable inhibition zone than the standard drug Ketoconazole. Thus these compounds can be used as a standard drug having fewer side effects.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş