The isolated compounds from methanolic extracts from Solanum xanthocarpum berries was evaluated for antiurolithiatic activity on rodent. First isolated compound was solasonine, a glycoalkaloid of Solanum xanthocarpum was given in a dose of 80 mg/kg of body weight in vehicle water. The second compound isolated was solasodine, a steroidal aglycone of Solanum xanthocarpum was given in a dose of 80 mg/kg of body weight in vehicle 1% CMC. Na+ and K+ ion concentration in urine were evaluated using Flame Photometer. For isolated compound solasonine ratio(Vt/Vc) obtained 1.6 and for second compound, solasodine 1.5, which was one of the criteria for antiurolithiatic activity and also significant difference in Na+ and K+ ion concentration was observed in both isolated compounds, that was indicated that solasonine showed good activity as natriuretic activity compared to solasodine.