Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Aqua mediated sodium acetate catalysed one-pot synthesis of pyrimidine derivatives as anti-inflammatory and antioxidant agent

Author(s): Dipen K. Sureja, Sandip P Dholakia and Kantilal R Vadalia

The present investigation is focused on one pot synthesis of 6-amino-5-cyano-4-substituted-2-(hydroxy/mercapto) pyrimidine derivatives with the objective of discovering a novel and potent anti-inflammatory and antioxidant agent. The formation of compounds was recognized by preliminary laboratory techniques like melting point, Rf value and further confirmed by spectral analysis. Furthermore, they were screened in-vitro to study their anti-inflammatory and antioxidant activity, which shows moderate to good potency.

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