Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-one using Layered Double Hydroxide (LDH) as a eco-friendly catalyst

Author(s): N. S. Ghotkar and B. N. Berad

Three component condendensation of B-keto ester, aldehyde and urea or thiourea catalyzed by layered double hydroxide ( LDH) to give 3,4-dihydropyrimidin-2(1H)-one is described. Catalyst has high region specific and chemo selective activity as well as no toxicity. It is cheap eco-friendly and easily synthesized catalyst. The mild reaction conditions, easy isolation of the product and high yields are the important features of this protocol.


ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?