Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-one using Layered Double Hydroxide (LDH) as a eco-friendly catalyst
Author(s): N. S. Ghotkar and B. N. BeradThree component condendensation of B-keto ester, aldehyde and urea or thiourea catalyzed by layered double hydroxide ( LDH) to give 3,4-dihydropyrimidin-2(1H)-one is described. Catalyst has high region specific and chemo selective activity as well as no toxicity. It is cheap eco-friendly and easily synthesized catalyst. The mild reaction conditions, easy isolation of the product and high yields are the important features of this protocol.
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Citations : 25868
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