This cross-sectional study was conducted on 350, unrelated young women, aged between 20 and 30 years. They are assembled according to WHO classification into three groups; normal weight (n=100), overweight (n=120) and obese (n=130). Interleukin-6 (IL-6) and C-reactive protein (CRP) were measured using standard methods and ELISA (R&D Systems. Insulin resistance was detected by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Anthropometric measures of adiposity showed significant positive correlations with inflammatory biomarkers (IL-6 and CRP) and inverse correlations with serum adiponectin levels (p<0.05). Obese and overweight women had significant lower serum adiponectin concentrations than normal weight women. In addition, significant negative correlation between serum adiponectin levels and inflammatory biomarkers was observed. Multivariate logistic regression analysis shows that increased WHR, WC and elevated blood pressure level are predictor’s risk factors for IR in obese/overweight women. The study highlights correlation of the obesity parameters to metabolic and biochemical markers in obese and overweight Egyptian women. Central obesity is a risk factor for IR in overweight/obese women. The study observed link between adiposity, IR and lipid metabolism. Dyslipidemia, hypertension and elevated inflammatory markers are the most prevalent metabolic parameters in overweight/obese women. Thus, investigate of anthropometric and biochemical profiles might be clinically important for risk estimation of chronic diseases. Conclusion: Alterations in metabolic profile and inflammatory markers may be due to excess of body fat and this may predispose to increase cardio metabolic risks at this young age Egyptian women.