Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Bis-N-aryl-β-lactams: Vilsmeier Reagent as an efficient entity for the Synthesis via Alternate Cycloaddition Reaction and In vitro Biology

Author(s): Parvez Alia, Jyotsna Meshrama, Vandana Tiwaria, Rajendra Dongrea Javed Sheikh, Mudrika Ahemad

A practical synthesis of cis bis-β-lactams has been executed using Chloromethylenedimethylammonium chloride (Vilsmeier reagent), prepared easily from N, Ndimethylformamide and Phosphorus Oxychloride in situ. It works out as a versatile acid activator reagent for the direct [2+2] ketene–imine alternate cycloaddition of aromatic acetic acid and bis-imines in one-pot synthesis under mild reaction conditions proving as a high yielding protocol for bis-β-lactam. This protocol has been proved to be high yielding, efficient and cheap for cis bis-β-lactam synthesis. Some of physic-chemical properties associated with bis-β-lactam have been discussed.

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