Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Chemical constituents of Syzygium samarangense

Author(s): Consolacion Y. Ragasa, Francisco C. Franco Jr., Dennis D. Raga, Chien-Chang Shen

The dichloromethane extract of the leaves of Syzygium samarangense (Blume) Merr. & Perry afforded 2¢,4¢- dihydroxy-6¢-methoxy-3¢-methylchalcone (1), 2¢,4¢-dihydroxy-6¢-methoxy-3¢,5¢-dimethylchalcone (2), 2¢-hydroxy- 4¢,6¢-dimethoxy-3¢-methyl chalcone (3), squalene (4), betulin (5), lupeol (6), sitosterol (7), and a mixture of cycloartenyl stearate (8a), lupenyl stearate (8b), β-sitosteryl stearate (8c), and 24-methylenecycloartenyl stearate (8d). The structures of 1-3, 5, 7, and 8a-8d were elucidated by 1D and 2D NMR spectroscopy. Sample 8 was tested for hypoglycemic and antimicrobial potentials. It showed negative hypoglycemic potential and exhibited moderate antifungal activity against C. albicans, low activity against T. mentagrophytes and low antibacterial activity against E. coli, S. aureus and P. aeruginosa. It was inactive against B. subtilis and A. niger.

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