Hepatotoxicity is mainly caused by the inorganic compounds, organic agents and synthetic drugs. These inorganic compounds, organic agents and synthetic drugs which undergo metabolism in the liver and produces free radicals in the liver which causes liver damage. Drugs such as Statins, Methotrexate, Paracetamol, Alcohol etc are some common hepatotoxic agents. Approximately 75% of idiosyncratic drug reactions results in liver transplantation or death. These hepatotoxic drugs mainly increase the transaminase liver enzyme i.e. SGOT, SGPT and ALP level which is very much effective marker of liver disease. This review throws light on various drugs which induce hepatotoxicity with the overview of their common mechanism.