Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Chiral Analysis Control of Three Nonsteroidal Anti-inflammatory Drugs by HPLC Methods

Author(s): Ameur M, Belboukhari N, Sekkoum K, Djeradi H, Cheriti A

The liquid chromatographic enantiomer separation of three (unused, used and expired) nonsteroidal anti-inflammatory drugs (NSAIDs) was performed on covalently immobilized and chiral stationary phases (CSPs) (Chiralpak IA and Chiralpak IB) and coated-type CSPs (Chiralpak AD, Chiralcel OJ, Chiralcel OD-H and Chiralcel OD) derived from polysaccharide derivatives. The results indicated that Chiralpak AD showed higher enantiomer separation than other column.


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