Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Comparative studies of novel triazole derivative having chiral center and their antimicrobial activities

Author(s): Bhavnaben D. Mistry*, Kishor R. Desai and Sanket M. Intwala

(-)5-[(1S)amino (2-chlorophenyl )methyl]-4-substituted phenyl-1,2,4-triazole-3-thiol (11a-j) & (+)5- [(1S)amino (2-chlorophenyl) methyl]-4-substituted phenyl-1,2,4-triazole-3-thiol (12a-j) have been synthesized by the reaction of (-)5-[(1S)amino(2-chlorophenyl)methyl]-1,3,4-oxadiazole-2-thiol (9) & (+)5-[(1S)amino(2-chlorophenyl)methyl]- 1,3,4-oxadiazole-2-thiol (10) with con. H2SO4, L(+) Tartaric acid, L(-) Tartaric acid, Hydrazine Hydrate, carbon disulfide and Various aromatic amine respectively. These compounds have been screened for their antibacterial and antifungal activities against different microorganisms. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR,13C NMR and mass spectral data.

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