GET THE APP

Computer Aided Drug Studies of Benzimidazole Containing Isoxazole Derivatives as Targeted Antibiotics | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Computer Aided Drug Studies of Benzimidazole Containing Isoxazole Derivatives as Targeted Antibiotics

Author(s): Siva Kumar R, Kumarnallasivan. P, Vijai Anand P.R, Pradeepchandran. R, Jayaveera K.N and Venkatnarayanan. R

Molecular docking is routinely used for understanding drug-receptor interaction in modern drug design. Here we described the docking of benzimidazole containing isoxazole derivatives as inhibitors to Escherichia coli. The inhibitory activities against Escherichia coli β-ketoacyl-acyl carrier protein synthase III (ecKAS III) were investigated by molecular docking using the HEX docking software. All the designed compounds were showed good binding energy when compared with the binging energies of standard drugs such as Ciprofloxacin (-211.04), Amoxilin (-182.23) and cefotaxime (-207.62). Among all the designed compounds, the compound 3 shows more binding energy values (-298.32). Further we planned to synthesis these benzimidazole derivatives and screen for in-vitro anti bacterial effect on Escherichia coli and other micro organisms.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry