Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Cyclization of biologically active furan derivatives

Author(s): Biplab De2, Sandip Sen1*, Sandeep Murya1 and T. S. Easwari1

The present work involved cyclization of imines by reaction with chloro-methylene chloride using 1,4-dioxane as solvent (2a-2c) . The cyclic derivatives were found to be associated with various diverse pharmacological activity such as antimicrobial. Prior to determination of the pharmacological activity LD50 was determined. The pharmacological data obtained were tested for statistical significance.


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