GET THE APP

Design and Synthesis of Benzodiazepines Bearing Benzimidazole / Benzothiazole and Indole Moieties as A Potent Antimicrobial and Antioxidant Agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Design and Synthesis of Benzodiazepines Bearing Benzimidazole / Benzothiazole and Indole Moieties as A Potent Antimicrobial and Antioxidant Agents

Author(s): Basavaraj S Naraboli, JS Biradar

In the present work 2-((1H-benzo[d]imidazol-2-yl)thio)-N-(4-(4-(1H-indol-3-yl)-8-methyl-1H-benzo[b][1,4]diazepin-2-yl)phenyl)acetamide 3ad, N-(4-(4-(1H-indol-3-yl)-8-methyl-1H-benzo[b][1,4]diazepin-2-yl)phenyl)-2-((5-methoxy-1H-benzo[d]imidazol-2-yl)thio)acetamide 4a-d and N-(4-(4-(1H-indol-3-yl)-8-methyl-1H-benzo[b][1,4]diazepin-2-yl)phenyl)-2-(benzo[d]thiazol-2-ylthio) acetamide 5a-d were synthesized in good yield in in-situ by cyclization of chalcones with substituted ortho-phenylenediamine. The chalcones were in turn prepared by Claisen–Schmidt condensation 2-(1H-benzo[d]imidazol-2-ylthio)-N-(4-acetylphenyl) acetamide and various 2, 5-disubstituted indole-3-carboxaldehydes in the presence of piperidine. The structures of all the newly synthesized compounds were characterized by their IR, 1HNMR, mass spectral studies and elemental analysis. All these compounds were screened for their in-vitro antimicrobial activity by agar plate diffusion method, Antioxidant activities: like, 1,1-Diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity (RSA), Ferric ions (Fe3+) reducing antioxidant power (FRAP), Ferrous (Fe2+) metal ion chelating activity. Some of the compounds have shown potent anti-microbial activity against all the screened bacteria and fungi and some have exhibited very good antioxidant activity.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry