Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Design and synthesis of some imidazole derivatives containing 2-(4-chlorophenyl)-4, 5-diphenyl imidazole moiety as anti-inflammatory and antimicrobial agents

Author(s): Iftikhar Ahsan, K. K. Sharma, Arun Sharma, Suroor Ahmed Khan, Uzma Khan

A series of imidazole derivatives (4 a-e) have been synthesized from 2-(4-chlorophenyl)-4, 5-diphenyl-1H-imidazole- 1-yl)-acetic acid hydrazide under various reaction conditions. Elemental analysis, IR, 1H NMR and mass spectral data confirmed the structure of the newly synthesized compounds. All the synthesized imidazole derivatives have been investigated for their anti-inflammatory, anti-bacterial and antifungal effect and showed moderate to good activity.


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