Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Design, synthesis and spectral characterisation of novel acyclic ligand and their transition metal complexes as selective DNA binding agents

Author(s): C. Joel, S. Theodore David, R. Biju Bennie, S. Daniel Abraham, S. Iyyam Pillai

Novel Co(II), Ni(II), Cu(II) and Zn(II) complexes have been designed and synthesized using the Schiff base ligand derived from 9,10-phenanthrenequinone and benzylamine. The ligand and its complexes have been characterized by analytical and spectral techniques. The higher conductance values in DMSO indicate that the complexes are 2:1 electrolytes. On the basis of electronic spectral investigations square planar geometry was assigned to Co(II), Ni((II) and Cu(II) complexes. The interaction of the complexes with CT-DNA has been explored by absorption, emission, circular dichoric and viscosity measurements. The complexes exhibited hypochromicity in absorption, which revealed that the complex bound to CT-DNA through an intercalation mode.

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