GET THE APP

Design, Synthesis and Studies of Structure Activity Relationship of �³-butyrolactones for Evaluation of Analgesic Activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Design, Synthesis and Studies of Structure Activity Relationship of �³-butyrolactones for Evaluation of Analgesic Activity

Author(s): Anuruddha R Chabukswar, Bhanudas S Kuchekar, Pradeep D Lokhande, Swati C Jagdale, Vishnu P Choudhari, Vasant V Chabukswar, Jaiprakash N Sangshetti, Atul A Baravkar, Nitin S Shinde, Mayuri N Mohokar, Sunit R Bhagade

Substituted Phenyl acetic acids have been used for the synthesis of various γ-butyrolactone. γ-butyrolactone compounds were designed by docking studies with cycloxygenase II active site. Thirteen compounds of γ-butyrolactone have been synthesized, characterized and subjected for analgesic activity in mice by hot plate method. Some of the compounds have been found to show better hydrogen and hydrophobic interactions with the cyclooxygenase enzyme. Out of 13 compounds 05 compounds have shown significant analgesic activity and can serve as future potential to be active as analgesic agents by inhibiting cyclooxygenase II enzyme. It has been observed that the analgesic activity of the compounds depends on the structure activity relationship of certain functional group. Structure activity relationship studies shows that by introduction of groups like halogens, hydroxyl and methoxy group plays a prominent role in enhancing analgesic activity of the substituted butyrolactones.


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry