Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Determination of chemical potential for carvedilol, atenolol and Propranolol diffusion through SDS micelle solution

Author(s): Oraas Adnan Hatem, Falah Shareef Abed Suhailand Amer Mousa Juda

Spectroscopic measurements of pharmaceutical compounds in phosphate buffer solution was conducted, compounds gave clear absorption peaks at 241 nm, 224.6 nm 289nm for carvedilol, atenolol and Propranolol respectively ,which is consistent with the standard values. The study of the spectroscopic properties of these compounds in polar and non-polar medium showed that the value of the extension coefficient and ʎmax reduced in the non-polar medium. The compounds showed a high stability with time in pH 7.4. Decomposition constants were calculated for each compound, and from which the half-life was calculated. Diffusion rate of pharmaceutical compounds through SDS micelles solution (an alternative model for cell membranes) with a concentration of 0.2 ×10-2 M was studied, and the chemical potential of each case was calculated and showed that Carvedilol can diffuse from the aqueous medium to inside micelle in a rate constant of 16.56× 10-3 min -1, for Atenolol it is 18.913×10-3 min-1 and 15.789 ×10-3min -1 for Propranolol. The equilibrium constants for diffusion rate were determined and found to be 3.04109, 1.102039 and 1.923079 min-1for Carvedilol, Atenolol and Propranolol respectively. The chemical potential also detected for the diffusion of each pharmaceutical compound, were found to be -2.8667,-0.25043 and -1.68547KJ.mol-1 respectively, which mean that the diffusion process was spontaneous for all compounds


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