Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Development and validation of RP-HPLC method for nifedipine and its application for a novel proniosomal formulation analysis and dissolution study

Author(s): Krishna Sanka, Rakesh Gullapelli, Narmada Patil, Padmanabha Rao A and Prakash V Divan*

The aim of the present study was to develop and validate a simple RP-HPLC method to determine nifedipine in a maltodextrin based oral proniosomes, bulk and marketed preparations. A method was carried out on a 5μm particle octadesyl silane (ODS) column (250 x 4.6 mm i.d) with acetonitrile, 0.1% (v/v) TEA (pH 7.4) 78:22 (v/v) as a mobile phase at a flow rate of 1mL/min and quantification was achieved at 326 nm. The linear range and correlation coefficient (r2) was found 625 to10000 ng/mL and 0.999 respectively. The proposed method was found to be simple, precise, suitable and accurate for quantification of nifedipine in a novel maltodextrin based oral proniosomes, bulk drug and marketed tablets.


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