Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Development and validation of spectrophotometric method for the estimation of cefepime in bulk and dosage form

Author(s): Chafle D. M.

A simple, accurate, precise and sensitive spectrophotometric method for estimation of cefepime in bulk and dosage form was developed. The method is based on the formation of red coloured complex with 1, 10 phenonthroline in presence of Ferric nitrate in aqueous medium. The coloured species exhibiting maximum absorption at 515 nm. Beers law was obeyed in the concentration range of 0.28 – 7.26 μg /ml with correlation coefficient 0.998. The linear regression equation obtained by least square regression method were y = 0.094 x + 0.152, where y is the absorbance and x is the concentration of the pure drug solution. The method was validated for several parameters like accuracy and precision. The values of relative standard deviation and % recovery were found to be satisfactory, indicating that proposed method is precise and accurate and hence can be applied for the routine analysis and quality control of cefepime in bulk as well as dosage form.

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