Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Development of analytical method for determination of quetiapine fumarate in bulk & tablet dosage form

Author(s): Pramod L. Ingale, Sampada D. Dalvi, Sachin V. Gudi, Laxmileena D. Patil,Deepali D. Jadav and Yogita A. Kadam

A new, simple, specific, sensitive, rapid, accurate and precise RP-HPLC method was developed for the estimation of quetiapine fumarate in bulk and pharmaceutical formulations. Quetiapine fumarate was chromatographed on Microsorb-MV 100-5 C-18 (250 x 4.6mm, 5 μm) column using UV detector. The mobile phase consisting acetonitrile and phosphate buffer (pH 3) in the ratio of 50:50 (v/v) at a flow rate of 1.0 ml/min with detection at 292 nm. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.


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