Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Development of new and rapid method for UV spectrophotometric determination of Labetalol in marketed formulations

Author(s): Manasa O, Ravindra Reddy K, Venkatesh P, Hepcykala Rani D, Sirisha G and Sahithireddy P

A simple, rapid, and sensitive UV spectrophotometric method has been developed and validated for the determination of Labetalol in pharmaceutical preparations. The method was developed utilizing 0.5N Sodium Hydroxide. The standard and sample was scanned and the absorbance is scanned at 245.3 Linearity was observed in the concentration range from 20-45 μg/ml with a correlation coefficient (R2) greater than 0.998. The method was validated by following the analytical performance parameters suggested by the International Conference on Harmonization (ICH). All validation parameters were within the acceptable range. Under experimental conditions described, calibration curve, assay of tablets and recovery studies were performed. Parameters of validation prove the precision of the method and its applicability for the determination of Labetalol in pharmaceutical tablet formulations. The method is fast and is suitable for high throughput analysis of the drug.

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