Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Dodecylbenzenesulfonic acid catalyzed one pot effic ient synthesis of 2-substituted benzimidazole

Author(s): Mantosh B. Swami and Sudhakar G. Patil a

Synthesis of various benzimidazole derivatives by t he reaction of o-phenylene diamine with substituted benzaldehyde in presence of dodecylbenzenesulfonic acid as catal yst. The reaction is performed in ethanol-water at room temperature. Furthermore, a series of compounds we re synthesized and characterized by melting point, NMR and IR tools. The method was proved to be simple, conve nient, ecofriendly and product was isolated with go od yield.


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