Chalcones are important intermediates for the synthesis of many flavones and chromones molecules. A fast and very rapid procedure is reported for the synthesis of chalcones from the ketones and aldehydes under the microwave (MW) irradiation. The chalcones were produced via the condensation reaction under microwave conditions during 20-60 seconds. Excellent yields were obtained in microwave-enhanced synthesis as compared to the conventional procedure. All these chalcones were screened for their in vitro antibacterial and antifungal activities. Most of the chalcones were found to have very promising antibacterial and antifungal activities.